People must avoid taking this medication if they have liver disease or consume alcohol heavily, have hepatitis, or take other medications that can cause liver damage. It can also cause life threatening liver damage. Should a person become pregnant while taking it, it requires a washout of the body within 2 years of taking it. Leflunomide can harm a fetus, and it can stick around in the body for 2 years. It can also cause gastrointestinal symptoms such as nausea, vomiting, heartburn, headache, and rash. Sulfasalazine can also reversibly lower the sperm count in men. Those taking methotrexate should not drink alcohol since both can damage the liver. Methotrexate is also an abortifacient, and pregnant people or people who plan to become pregnant must avoid it due to its harmful effects on a fetus. Methotrexate can cause liver damage and lung inflammation, leading to scarring or fibrosis. Side effects of conventional methotrexate and sulfasalazine include bone marrow suppression. It may also cause headaches and symptoms like cough, runny nose, or fever. Otezla may also irritate the gastrointestinal tract and lead to issues like abdominal pain, diarrhea, nausea, and vomiting. These drugs can also lead to heart problems, kidney damage, and in rare cases, liver damage. NSAIDs can irritate the gastrointestinal tract, which may cause an ulcer or gastrointestinal bleeding. What are the downsides, including risks and side effects? Different JAK inhibitors block different inflammatory proteins.Ħ. JAK inhibitors interfere with this signaling process. Cytokines are proteins in the body that signal cells to produce inflammation. To prevent inflammation, targeted synthetic DMARDs inhibit the JAK family of proteins, including JAK 1, 2, and 3 and tyrosine kinase 2. This helps decrease inflammation in the body, which can help improve psoriatic arthritis symptoms.Ĭonventional DMARDs work broadly throughout the body to slow disease progression and prevent irreversible, permanent joint damage that can otherwise occur with long-term joint inflammation. Otezla blocks the making of the enzyme phosphodiesterase 4. However, they do not work to slow disease progression. This leads to decreased production of prostaglandins, or hormone-like substances that bring on joint and spine pain and inflammation. They work quickly by blocking the enzymes cyclo-oxygenase 1 and 2. NSAIDs are anti-inflammatory medications that people can take for mild psoriatic arthritis to treat joint pain, stiffness, and swelling. What are the differences between each of these oral medications?
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